As of right now, I've only been through one heroic. As usual though, I wasn't able to build my dps up to a good amount. As was the case in heroics prior to the patch. Because of this, I tend to just aoe mobs.
I've only played around with destro.
This is the spec I've seen mentioned in a few threads on other sites: click
This is the spec I use: click
The reason I didn't go with the same destro points as the other is because I felt those talents were more pvp. I'm strictly a pve player.
The points into Doom and Gloom, I may change.
So if you're interested in destro, the above 2 specs are worth looking at. Other specs, I'm unsure of at this point. Have you looked at elitistjerks? I saw a spec thread there, with stat priority and possible glyphs.