I'm sure you all know that Garrote at lv 60+ silences the enemy for 3 sec. along with the DOT.
At lv 60+, what would be more preferable against clothies: Ambush or Garrote? In other words, a huge damage spike or a slow damage over time and a long silence? Obviously, you'll be using Garrote if you're using anything but daggers, but what if you're using daggers?
Against Mages, they won't be able to blink after the initial Garrote. Say bye to Frost Nova too. Against casters in general, you can perform a "silence lock" of sorts, although it's a very situational one.
Garrote>Imp. Kick>Arcane Torrent (Blood Elf Racial)>Cloak of Shadows (for near spell immunity after the "spellock")
Or if you're not a Blood Elf with Imp. Kick, you can try this if you're Sub specced:
Premed>Shadowstep>Garrote>Backstab/Hemo/SS>Rupture
(Thanks to Sensou on the Wowhead Garrote comments for the above combos)
Positive feedback=appreciated.