everyone's playstyle is different. Some are clickers, some are keyboarders, most are hybrid between the two.
I personally use Bongos to setup my Action bars and I will try to describe how I set them up that works very well for me.
-------------- X X X X X
| | y yy yy y uuuuu oooooooooo
-------------- ZZZZZZZZZZZZZZZZZZ mmmmm qqqqqqqqqq
That is what the bottom half of the screen looks like for me.
The big box is the chat window
X = A scaled up button (150%), I use that for what I click, Example: on my rogue I have BG Trinket, Racial, Vanish, Prep, Blind, Evasion on there.
y = normal scale (100%), less used icons. Rogue Example: I have Distract, and Feint on there.
z = normal scale (100%) combat buttons all bound to keyboard. Rogue Example: SS,backstab,evis,etc,etc
u and m= scaled down a bit buttons(70%) used for various potions/bandages etc.
o and q = Things like poisons, cooking,first aid, food, etc.
The logic behind it is that the scaled up buttons (X) are easy to click and monitor cooldowns since they are 150% bigger.
The middle row (Y) is still accesible but are tucked out of the way and usually lined up between the gaps in row X. (for "X" I try to leave 1 blank button between each action to remove the chance of clicking wrong.)
Everything else I need is still in the bottom half of the sceen (I use a widescreen monitor which helps) Leaving the top half of the screen pretty much clutter free.
I use this button layout on ALL my characters and it works wonders for me. I spend less time hunting for the right button to click and more time killing things.
If you need a screenshot to better see what I mean let me know and I will try to post one.
^^damn typos.
Edited, Dec 20th 2006 11:33am by TseTsuo