Wait, what? No you can't. It might be different on console, but you can't even bring up the skills window during combat on PC. You're locked into whatever you have at the time at the start of combat.
Definitely different on the console. Unless my game is just bugged to the point where it really likes me.
Anyway, do you know if they're bringing 2.0 to the PS3? Because you don't see a ton of drops to begin with, and it's getting really annoying playing my DH, because pretty much all my weapon upgrades have to come from vendors. It's really quite frustrating.