If you use poison stock up.Follow

I learned the hard way to stock up on poisons before entering an instance. I thought 10 instant would be enough to carry me through as the combats started lasting longer and the poison procs started ticking away I found myself running out of poison well before the cool down period. Needless to say, you can't simply pop off and get a refill when you run out, and my damage dropped noticeable once the poison was gone.

So if you use poison, remember to keep a good supply on hand, especially if you are running off into an instance.

Mind numbing poison is a waste of resources anywhere other than caster bosses (like Doan in Scarlet Monastery). Since bosses cannot be stunned or interrupted while casting, it's pretty much the only excuse to use that poison. Whitemane in SM doesnt cast anything damaging enough to warrant casting time reduction... and as far as I remember you can't stun her either. Deadly psn is worthless anywhere anytime. DoT in 10sec battles, no thanks. Crippling poison is awesome for pretty much every instance, so keep it on main weapon, as when you pull (hopefully you are the one pulling) you get a chance to slow them down on their way back and not get owned while running back to your party. Then again, if the sap timer is running, that might not be such a good idea.

Instant Poison is the only poison worth your time essentially, as it deals poison dmg instantly and stacks very nicely with fast weapons like daggers or fastest swords.

Having said that, the above only applies to PvE. PvP is a completely different story. ^^