Too many games are now available for this to be a minor reply post.
First, if you haven't seen, a new Humble Bundle was released last week? Anyway, 4 more games have been added for a total of seven games:
Voxatron (still in alpha, but good game nonetheless, will come with further updates)
Blocks that Matter
Binding of Isaac
Zen Puzzle Garden
I haven't had a chance to try out the four games recently added, but Voxatron and Isaac are enjoyable- Isaac is like shooting your way through a random Zelda dungeon. Be aware there are only a few days left for this bundle.
Secondly, there's a new Indie Royal bundle available at http://www.indieroyale.com/. Not sure if this one is worth picking up, but there are five games:
Fate of the World
Ben there, Dan that!
Time Gentlemen, Please
From youtube, I thought Scoregasm looked interesting enough alone for me to spend $5.00 on this. The last two were created with the Monkey Island games in mind, which I enjoyed, so I might pick this up simply to see how those games play out.
Skyrim launch this week is not making things easy at all.