I have only ever used ProfitUI
(it was what my guild mate suggest to me when I first started playing, as it was the one he had installed). One of the main features I like about it is you have 'quick' keys, in your group window (some pre-set spells & cures). You can modify the preset spells, though I found it a little difficult. The cures are absolutely brilliant to have.
It also has an Auto-Updater...so you can run it before your game to update any UI files, then have it set to launch your game as well. Again, this can be changed. :) For instance I have mine set to launch EQ2 Map...which then launches my game for me. Edited, Aug 17th 2012 12:23pm by Dyadem