Nah, only 3/3 HQ for Cashmere right now, but I have an RNG heavy strat that the longer I synth, the greater my chance of HQ, and I can milk it for all it's worth (I average ~2,600 Quality on any given synth no matter the star rating, which puts me at ~80-90% if I don't get lucky. Bad luck, 18%, and I still HQed, good luck, 100%).
I haven't HQed Wolfram Ingots, or Cashmere cloth, but I have once with Terminus putty:). However, I have made a few of the heavy armor (I forget which ones), and NQed only one, and then my recent luck with Cashmere gear, I actually am doing better than people have implied I should be doing.
As for creating the 50x items, I do that while watching TV, I only have about 5 NQ when I get my 50 HQ. And I am sure most of those are because I get distracted, or lose track of where I am at.
The pain was farming the ingredients, the crystals, and shards... Then, like the Leather for example, with the 2 camp grounds for Hippogryph tha tI found, it took me ~2 1/2 hours for that, another hour for Shards, and ~ another 1/2 an hour for the Black Alumen. It took ~3 hours to make all of the hippogryph leather (which ironically I had my worst failure rate ever with, 26 NQ, 74 HQ... But that really was me not paying attentions). So, I had to go back out and farm more of everything.
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