Post adjustment neo nyzule is borderline sadistic with its 25 runs per key item tweak (that's honestly a very high number for one piece of gear).,
You only need to clear F100 once for the key item, though.
It's only 25 clears if you shoot for F80 instead, but who's gonna bother doing that? If F100 is impossible for you to reach, it's not like F80 is gonna be a cakewalk in comparison. Chances are any group that can occasionally make it to F80 will be able to manage a few F100s if they just kept going.
Don't get me wrong, it's still a sadistic event.